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Topic: So I went to Neurologist Last Night (Read 410 times) |
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stuey
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So I went to Neurologist Last Night
« on: May 21st, 2003, 8:25am » |
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Hi I am pretty new to the site and don't really know if anyone would take my advice serious but I went to the neurologist that treated me for nocturnal seizures last night. I sit down devastated and we get to talking and he ends up giving me samples of neurontin and i take a 600 mg pill last evening and I already take the verapamil. Lo and behold no attack last night. I also asked if taking the triptans would prolong the cycles and he said no and that people do more worrying about heart problems from triptans than are necessary. He gave me some new sample of a triptan called Relpax which he said has quite a bit of a longer half life than Imitrex. They were tablets though, no injections. If anybody is interested ask your doctor about Relpax. I wonder though if the cycle is almost over and that's why no attack last night. They have been on me since mid-April. Anyway, if the neurontin helped great. I will take another this evening. So that's about it. Nothing funny to say today, just wanted to add my little stuff from last night and hope it helps someone. Peace to all. Stu
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Marc
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Re: So I went to Neurologist Last Night
« Reply #1 on: May 21st, 2003, 9:37am » |
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Stuey,
Thanks for the heads up on the new Triptan - I hadn't heard about it yet. Keep us updated on your progress.
Marc
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aprilbee
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Ain't I a stinkah!!
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Re: So I went to Neurologist Last Night
« Reply #2 on: May 21st, 2003, 9:42am » |
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I also took Relpax during my last cycle and it seemed to work pretty good, however like you, I was close to the end of my cycle and so I don't know if it was the Relpax or just the end of my cycle. I will DEFINATELY try it on my next attack.
PFDAN to all ;D
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Major_Headcase
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Re: So I went to Neurologist Last Night
« Reply #4 on: May 21st, 2003, 10:19am » |
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I'm not sure I understand ... I thought triptans were to abort attacks in progress, but it sounds like you used Relpax as a "preemptive strike" abortive, almost a preventative? Does your doc have you take it daily before an attack or in response to an attack? ???
Please do keep the board informed on Relpax. I'm between cycles right now but always looking for new ammo for the next battle!
-John
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| « Last Edit: May 21st, 2003, 10:20am by Major_Headcase » |
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stuey
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Re: So I went to Neurologist Last Night
« Reply #5 on: May 21st, 2003, 10:25am » |
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John, I didn't take the Relpax at all last night. I took the 600 mg of neurontin last night and didn't have an attack. I don't know how well Relpax works at all, just that it has supposedly considerably more of a half life than does imitrex. I have never taken it, just am armed with a few Relpax in case of another attack. I am sorry if I wasn't clearer. I just wanted folks to know about Relpax, not that I have taken it yet cause I haven't. The doctor just gave me a few samples of it. Ihope that clears it up. Peace. Stu
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cbolony
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I love YaBB 1G - SP1!
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Re: So I went to Neurologist Last Night
« Reply #6 on: May 21st, 2003, 11:29am » |
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My neuro gave me some sample Relpax in march to
try out its ok for my low kips i can stand waiting 30-40
mins till it kicks in.But when my CH are high on the kip scale i know only one drug that helps me and it's imitrex injections.The only problem is if you take relpax or frova
and they do not stop the CH you have to wait 24 hrs
before taking the imitrex injections.If i'am wrong about this can somebody please tell me.
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Major_Headcase
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Re: So I went to Neurologist Last Night
« Reply #7 on: May 21st, 2003, 11:38am » |
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Stuey,
"Oh!" ... yep, I was confused. Glad to hear the Neurontin helped ya'! Sorry I didn't read your post carefully enough, here's wishing you more PFDANs. -john
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Bob_Johnson
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Re: So I went to Neurologist Last Night
« Reply #8 on: May 22nd, 2003, 7:20am » |
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Expert Opin Investig Drugs 2001 Oct;10(10):1869-74
Eletriptan.
Gawel MJ, Grujich NN.
Division of Neurology, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, ON, Canada. marek.gawel@swchsc.on.ca
Eletriptan (Relpax, Pfizer) is one of a group of anti-migraine medications commonly referred to as 'triptans'. It is a potent serotonin agonist at the 5-HT(1B/1D) receptor and is indicated for the acute treatment of migraine headaches. Eletriptan is administered orally. It is rapidly absorbed and has a bioavailability of 50% compared to 14% for sumatriptan. The relatively high lipophilicity of eletriptan compared to sumatriptan may explain its faster oral absorption and shorter time to onset of action. Results from comparative studies between oral eletriptan and sumatriptan indicate that eletriptan 80 mg was superior to sumatriptan 100 mg in onset of action, headache response rate, pain free response rate and relief of associated migraine symptoms at the 1 or 2 h time intervals. Although there was a modest increase in adverse events with eletriptan 80 mg than with sumatriptan 100 mg, eletriptan received a high patient acceptability rating (84%).
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| « Last Edit: May 22nd, 2003, 12:03pm by Bob_Johnson » |
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Bob Johnson
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Bob_Johnson
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Re: So I went to Neurologist Last Night
« Reply #9 on: May 22nd, 2003, 12:05pm » |
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Good summary of several studies. You will have to slog through it to extract the important results--sorry!
==========
: Cochrane Database Syst Rev 2001;(3):CD003224 Related Articles, Links
Eletriptan for acute migraine.
Smith LA, Oldman AD, McQuay HJ, Moore RA.
ICRF/NHS Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Oxford, UK, OX3 7LF. l.smith@icrf.icnet.uk
BACKGROUND: Eletriptan (Relpax) is a new triptan soon to be made available by prescription for the treatment of acute migraine. Currently five triptans are available by prescription and more are under development. In light of the many drugs for treating acute migraine, there is a need for evidence-based assessments to help determine the relative efficacy and harm of these treatments. OBJECTIVES: To determine the efficacy of eletriptan for treating a single migraine attack using the outcomes of headache response and pain-free response at 0.5, 1, 2 and 4 hours, and sustained relief over 24 hours. To express efficacy in terms of number-needed-to-treat (NNT). To determine the adverse effects of a single dose of eletriptan and express this in terms of number-needed-to-harm (NNH). To allow for the comparison of the efficacy of eletriptan with other migraine treatments evaluated systematically in the same way. SEARCH STRATEGY: Data from all Phase III randomised placebo-controlled trials were made available by the manufacturer, Pfizer Inc. To date, these trials comprise the only data on eletriptan relevant to this review in a published or unpublished form; thus, searches of electronic databases for further trials of eletriptan were not conducted. SELECTION CRITERIA: Trials of eletriptan for acute migraine; randomised allocation to treatment groups, including a placebo group; double-blind design; International Headache Society diagnostic criteria for migraine with or without aura; single migraine attack; single-dose treatment at standard doses; adult population; baseline pain of moderate or severe intensity using a 4-point standardised rating scale (0 = no pain, 1 = mild pain, 2 = moderate pain and 3 = severe pain); and dichotomous or percentage data for at least one of the main efficacy outcomes. DATA COLLECTION AND ANALYSIS: Trials were scored for quality and data extracted by two independent reviewers. Dichotomous or percentage data were extracted and pooled to calculate the relative benefit (RB) or relative risk (RR) and NNTs or NNHs for a number of outcomes for eletriptan 20 mg, 40 mg and 80 mg. The main outcomes considered were headache response at 1 and 2 hours, pain-free response at 2 hours, sustained relief over 24 hours and adverse effects. Minor outcomes considered were headache response at 0.5 and 4 hours, and pain-free response at 0.5, 1 and 4 hours. MAIN RESULTS: Six trials met the inclusion criteria. Significant benefit of eletriptan over placebo was shown for eletriptan 20 mg, 40 mg and 80 mg for the primary efficacy outcomes of headache response and pain-free response at 2 hours. For headache response at 2 hours, the NNTs (with 95% confidence intervals) were 4.4 (3.4 to 6.2), 2.9 (2.6 to 3.3) and 2.6 (2.4 to 3.0) for eletriptan 20 mg, 40 mg and 80 mg, respectively. For pain-free response at 2 hours, the NNTs were 9.9 (6.9 to 1 , 4.5 (4.0 to 5.1) and 3.7 (3.4 to 4.2), for eletriptan 20 mg, 40 and 80 mg, respectively. There was no significant difference in the incidence of major adverse effects between any dose of eletriptan and placebo. The incidence of minor adverse effects was significantly higher for all eletriptan doses than for placebo, with NNHs of 11 (95% confidence interval, 6.2 to 39), 7.0 (5.2 to 11) and 3.7 (3.1 to 4.5) for eletriptan 20 mg, 40 mg and 80 mg, respectively. REVIEWER'S CONCLUSIONS: Eletriptan 20 mg, 40 mg and 80 mg are effective for the treatment of an acute migraine attack. Effectiveness is dose-related, with statistically significant differences between doses for pain-free response and 24-hour outcomes. Eletriptan compares well with other triptans available for outcomes measured up to 2 hours and provides meaningful relief for 24 hours. Taken as a single dose, eletriptan was well tolerated and caused no major harm. The incidence of minor harm was dose-dependent, with 80 mg giving significantly more adverse effects than 40 mg.
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Bob Johnson
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